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在 OpenClaw 中安装
/install primer-design-check
功能描述
Check primers for dimers, hairpins, and off-target amplification
安全使用建议
This skill is inconsistent: the documentation promises off-target BLAST and template-based analysis but the provided script only does simple local checks (Tm, GC%, naive hairpin/dimer heuristics). If you need off-target analysis you should not rely on this skill as-is. Before installing or using it: (1) review and test the script on non-sensitive example sequences; (2) don't assume it performs BLAST or template scanning — ask the author or implement proper BLAST integration (local BLAST+ or NCBI services) if needed; (3) run it in a sandboxed environment and validate edge cases (empty sequences, non-ATGC characters); (4) consider established tools (Primer3, Primer-BLAST) for production or experimental use; and (5) request fixes for the documentation-code mismatch and for basic input validation (avoid divide-by-zero and sanitize inputs) before trusting outputs for lab work.
功能分析
Type: OpenClaw Skill
Name: primer-design-check
Version: 1.0.0
The skill bundle is a legitimate bioinformatics tool for primer validation. The Python script (scripts/main.py) performs local calculations for melting temperature, GC content, and structural checks (hairpins/dimers) without any network access, file system manipulation, or external dependencies. The documentation (SKILL.md) contains standard instructions and a realistic security assessment with no evidence of prompt injection or malicious intent.
能力评估
Purpose & Capability
Name/description promise: dimer, hairpin, and off-target amplification. The included Python implements Tm/GC%, a simple hairpin and self-dimer heuristic, and prints results — but there is no off-target BLAST, no template-based off-target scanning, and no network or BLAST invocation in the code. The SKILL.md claims off-target BLAST results (and lists 'template' as a parameter) which the code does not implement; this is a clear mismatch between claimed capability and actual implementation.
Instruction Scope
SKILL.md parameters and returns suggest more functionality than exists (template input, BLAST). The runtime instructions and code operate locally and only read command-line arguments / print output. The SKILL.md also references file reads/writes and workspace outputs in the Risk Assessment, but the code only prints to stdout; those statements are misleading. The SKILL.md's security checklist and sandbox recommendations are generic and not enforced by the code. Also note minor missing input validation in code (e.g., empty sequence can cause division by zero when computing GC%).
Install Mechanism
No install spec; instruction-only skill with an included Python script. No external downloads, package installs, or unusual install behavior are present.
Credentials
No environment variables, credentials, or config paths requested — proportionate to the implemented local checks.
Persistence & Privilege
Skill does not request persistent or elevated privileges; always:false and no modifications to other skills or system configurations are indicated.
如何使用
- 确保已安装 OpenClaw（本地或 Docker 部署）
- 在对话框中输入安装命令：
/install primer-design-check - 安装完成后，直接呼叫该 Skill 的名称或使用
/primer-design-check触发 - 根据 Skill 的参数说明提供必要输入，即可获得结构化输出
版本历史
v1.0.0
primer-design-check v1.0.0 – Initial release
- Introduces an in silico tool for primer validation, checking for dimers, hairpins, and off-target amplification.
- Supports common applications such as qPCR, sequencing, and mutagenesis primer assessment.
- Provides Tm and GC% calculations, dimer/hairpin detection, and BLAST-based off-target analysis.
- Returns results and flags (e.g., dimer warnings) to guide primer redesign if needed.
- Includes a security checklist and risk assessment focused on local script execution.
元数据
常见问题
Primer Design Check 是什么？
Check primers for dimers, hairpins, and off-target amplification. 它是一个面向 Claude Code / OpenClaw 的 AI Agent Skill 插件，目前累计下载 94 次。
如何安装 Primer Design Check？
在 OpenClaw 或 Claude Code 对话框中运行命令「/install primer-design-check」即可一键安装，无需额外配置。
Primer Design Check 是免费的吗？
是的，Primer Design Check 完全免费，采用 MIT-0 许可证，可自由下载、安装和使用。
Primer Design Check 支持哪些平台？
Primer Design Check 跨平台运行，可在任意部署了 OpenClaw / Claude Code 的环境中使用（cross-platform）。
谁开发了 Primer Design Check？
由 AIpoch（@aipoch-ai）开发并维护，当前版本 v1.0.0。
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