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Install in OpenClaw
/install primer-design-check
Description
Check primers for dimers, hairpins, and off-target amplification
Usage Guidance
This skill is inconsistent: the documentation promises off-target BLAST and template-based analysis but the provided script only does simple local checks (Tm, GC%, naive hairpin/dimer heuristics). If you need off-target analysis you should not rely on this skill as-is. Before installing or using it: (1) review and test the script on non-sensitive example sequences; (2) don't assume it performs BLAST or template scanning — ask the author or implement proper BLAST integration (local BLAST+ or NCBI services) if needed; (3) run it in a sandboxed environment and validate edge cases (empty sequences, non-ATGC characters); (4) consider established tools (Primer3, Primer-BLAST) for production or experimental use; and (5) request fixes for the documentation-code mismatch and for basic input validation (avoid divide-by-zero and sanitize inputs) before trusting outputs for lab work.
Capability Analysis
Type: OpenClaw Skill
Name: primer-design-check
Version: 1.0.0
The skill bundle is a legitimate bioinformatics tool for primer validation. The Python script (scripts/main.py) performs local calculations for melting temperature, GC content, and structural checks (hairpins/dimers) without any network access, file system manipulation, or external dependencies. The documentation (SKILL.md) contains standard instructions and a realistic security assessment with no evidence of prompt injection or malicious intent.
Capability Assessment
Purpose & Capability
Name/description promise: dimer, hairpin, and off-target amplification. The included Python implements Tm/GC%, a simple hairpin and self-dimer heuristic, and prints results — but there is no off-target BLAST, no template-based off-target scanning, and no network or BLAST invocation in the code. The SKILL.md claims off-target BLAST results (and lists 'template' as a parameter) which the code does not implement; this is a clear mismatch between claimed capability and actual implementation.
Instruction Scope
SKILL.md parameters and returns suggest more functionality than exists (template input, BLAST). The runtime instructions and code operate locally and only read command-line arguments / print output. The SKILL.md also references file reads/writes and workspace outputs in the Risk Assessment, but the code only prints to stdout; those statements are misleading. The SKILL.md's security checklist and sandbox recommendations are generic and not enforced by the code. Also note minor missing input validation in code (e.g., empty sequence can cause division by zero when computing GC%).
Install Mechanism
No install spec; instruction-only skill with an included Python script. No external downloads, package installs, or unusual install behavior are present.
Credentials
No environment variables, credentials, or config paths requested — proportionate to the implemented local checks.
Persistence & Privilege
Skill does not request persistent or elevated privileges; always:false and no modifications to other skills or system configurations are indicated.
How to Use
- Make sure OpenClaw is installed (local or Docker)
- Run the install command in chat:
/install primer-design-check - After installation, invoke the skill by name or use
/primer-design-check - Provide required inputs per the skill's parameter spec and get structured output
Version History
v1.0.0
primer-design-check v1.0.0 – Initial release
- Introduces an in silico tool for primer validation, checking for dimers, hairpins, and off-target amplification.
- Supports common applications such as qPCR, sequencing, and mutagenesis primer assessment.
- Provides Tm and GC% calculations, dimer/hairpin detection, and BLAST-based off-target analysis.
- Returns results and flags (e.g., dimer warnings) to guide primer redesign if needed.
- Includes a security checklist and risk assessment focused on local script execution.
Metadata
Frequently Asked Questions
What is Primer Design Check?
Check primers for dimers, hairpins, and off-target amplification. It is an AI Agent Skill for Claude Code / OpenClaw, with 94 downloads so far.
How do I install Primer Design Check?
Run "/install primer-design-check" in the OpenClaw or Claude Code chat to install it in one step — no extra setup required.
Is Primer Design Check free?
Yes, Primer Design Check is completely free, licensed under MIT-0. You can download, install and use it at no cost.
Which platforms does Primer Design Check support?
Primer Design Check is cross-platform and runs anywhere OpenClaw / Claude Code is available (cross-platform).
Who created Primer Design Check?
It is built and maintained by AIpoch (@aipoch-ai); the current version is v1.0.0.
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