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版本数
在 OpenClaw 中安装
/install variant-pathogenicity-predictor-1
功能描述
Integrate REVEL, CADD, PolyPhen scores to predict variant pathogenicity.
安全使用建议
The included Python script is small and only computes a composite score from three numeric inputs; it does not implement VCF parsing, ACMG interpretation, CONFIG editing, or file-based reports despite SKILL.md claiming those features. Before installing or granting the agent permission to run this skill: (1) review scripts/main.py yourself — it currently only uses CLI flags (--revel, --cadd, --polyphen, --demo) and has no network or file-read behavior; (2) if you expect VCF support or report generation, require the author to provide the actual implementation or updated documentation; (3) run the script in a sandbox or isolated environment (python -m py_compile scripts/main.py and python scripts/main.py --demo) to confirm behavior; (4) avoid giving the agent access to sensitive files or directories until the skill's true I/O behavior is verified; and (5) ask the author to reconcile SKILL.md with the code and to pin dependencies and add tests if you plan to rely on it for clinical or sensitive decisions.
功能分析
Type: OpenClaw Skill
Name: variant-pathogenicity-predictor-1
Version: 1.0.0
The skill is a simple calculator for genetic variant pathogenicity based on numerical scores (REVEL, CADD, PolyPhen). The Python script (scripts/main.py) contains basic arithmetic logic with no network access, file system writes, or suspicious execution patterns, and the SKILL.md instructions are standard for an AI agent without any prompt-injection or exfiltration attempts.
能力评估
Purpose & Capability
The skill's stated purpose (integrate REVEL/CADD/PolyPhen to predict pathogenicity) matches the small script's core behavior (combine three numeric scores into a composite and classification). However, SKILL.md and metadata claim a broader feature set (VCF input, report.json output, ACMG guideline interpretation, multiple integrated scores beyond the three) that the code does not implement. This is a capability mismatch (overpromising).
Instruction Scope
SKILL.md instructs workflows that reference reading VCFs, writing output files, editing a CONFIG block, producing ACMG interpretations, and running more extensive pipelines. The actual script only accepts --revel, --cadd, --polyphen, or --demo and does not read files or produce structured reports. If an agent follows the SKILL.md literally it may attempt to access or modify files/paths that do not exist, leading to unintended file I/O or escalation of access beyond what the code needs.
Install Mechanism
No install spec — instruction-only plus a small included Python script. Nothing is downloaded or extracted. Low install risk.
Credentials
No environment variables, credentials, or config paths are requested. The skill does not ask for external API keys or sensitive tokens, which is proportionate for this functionality.
Persistence & Privilege
The skill is not marked always:true and requests no elevated or persistent privileges. It does not modify other skills or system config. Autonomous invocation is allowed by platform default and is not by itself a red flag here.
如何使用
- 确保已安装 OpenClaw（本地或 Docker 部署）
- 在对话框中输入安装命令：
/install variant-pathogenicity-predictor-1 - 安装完成后，直接呼叫该 Skill 的名称或使用
/variant-pathogenicity-predictor-1触发 - 根据 Skill 的参数说明提供必要输入，即可获得结构化输出
版本历史
v1.0.0
Initial release of variant-pathogenicity-predictor.
- Integrates REVEL, CADD, PolyPhen, SIFT, and MutationTaster scores to predict variant pathogenicity.
- Provides command-line interface for inputting single variants or VCF files, specifying gene and score types.
- Outputs include pathogenicity classification, ACMG guideline interpretation, individual score breakdown, and confidence assessment.
- Includes structured workflow, input validation, error handling, and explicit risk/security assessment.
- No extra Python dependencies required; packaged for reproducible, auditable execution via scripts/main.py.
元数据
常见问题
Variant Pathogenicity Predictor 是什么？
Integrate REVEL, CADD, PolyPhen scores to predict variant pathogenicity. 它是一个面向 Claude Code / OpenClaw 的 AI Agent Skill 插件，目前累计下载 90 次。
如何安装 Variant Pathogenicity Predictor？
在 OpenClaw 或 Claude Code 对话框中运行命令「/install variant-pathogenicity-predictor-1」即可一键安装，无需额外配置。
Variant Pathogenicity Predictor 是免费的吗？
是的，Variant Pathogenicity Predictor 完全免费，采用 MIT-0 许可证，可自由下载、安装和使用。
Variant Pathogenicity Predictor 支持哪些平台？
Variant Pathogenicity Predictor 跨平台运行，可在任意部署了 OpenClaw / Claude Code 的环境中使用（cross-platform）。
谁开发了 Variant Pathogenicity Predictor？
由 AIpoch（@aipoch-ai）开发并维护，当前版本 v1.0.0。
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