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Variant Pathogenicity Predictor

作者 EC-cyber258 · GitHub ↗ · v0.1.0 · MIT-0
cross-platform ⚠ suspicious
273
总下载
0
收藏
0
当前安装
1
版本数
在 OpenClaw 中安装
/install variant-pathogenicity-predictor
功能描述
Integrate REVEL, CADD, PolyPhen scores to predict variant pathogenicity
安全使用建议
This skill appears to be a draft with mismatched documentation and implementation. The code itself is simple and low-risk (no network, no credentials), but SKILL.md promises VCF parsing, gene context, and integration of additional predictors that are not implemented. Before installing or trusting results: (1) do not use this for clinical decisions — tests and validation are missing; (2) ask the author for the intended implementation or an updated release that actually parses VCFs and documents dependencies; (3) insist on input validation and path sanitization if file I/O is added; (4) inspect and test any future code that adds network calls or external data sources. Given the inconsistencies, treat this as incomplete/deceptive rather than malicious, but avoid relying on it until it is corrected and properly audited.
功能分析
Type: OpenClaw Skill Name: variant-pathogenicity-predictor Version: 0.1.0 The skill is a straightforward bioinformatics tool designed to calculate variant pathogenicity scores based on user-provided numeric inputs. The Python script (scripts/main.py) contains only basic arithmetic logic and lacks any high-risk capabilities such as network access, file system manipulation, or shell execution. No evidence of malicious intent, data exfiltration, or prompt injection was found.
能力评估
Purpose & Capability
Name/description claim integrating REVEL, CADD, PolyPhen and 'other scores' and support for VCF/variant/gene inputs. The actual script only accepts numeric --revel, --cadd, --polyphen flags (and --demo) and returns a simple composite — it does not parse VCFs, handle gene context, or call SIFT/MutationTaster. The declared capabilities are therefore disproportionate to the delivered code.
Instruction Scope
SKILL.md shows CLI usage for --variant, --vcf, --gene and output report.json and includes a security checklist expecting input validation and file I/O protections, but scripts/main.py does none of that. The runtime instructions would lead users to expect file reading/writing and VCF processing that the code doesn't perform — a scope mismatch that could confuse users and lead to improper use.
Install Mechanism
No install spec and only a small Python script with standard-library usage (argparse/json). No external downloads or package installs are required, which is proportionate to the actual shipped code.
Credentials
The skill requests no environment variables, credentials, or config paths. That matches the provided script which runs locally and does not perform network access or require secrets.
Persistence & Privilege
No special persistence or elevated privileges requested (always: false, no installs). The skill does not modify system or other skill configuration.
如何使用
  1. 确保已安装 OpenClaw(本地或 Docker 部署)
  2. 在对话框中输入安装命令:/install variant-pathogenicity-predictor
  3. 安装完成后,直接呼叫该 Skill 的名称或使用 /variant-pathogenicity-predictor 触发
  4. 根据 Skill 的参数说明提供必要输入,即可获得结构化输出
版本历史
v0.1.0
Initial release: Variant Pathogenicity Predictor - Integrates REVEL, CADD, PolyPhen-2, SIFT, and MutationTaster scores to assess genetic variant pathogenicity. - Supports single variant and VCF file input; outputs pathogenicity classification, ACMG interpretation, score breakdown, and confidence assessment. - Local script execution with no external API calls; reads input files and writes output reports. - Includes explicit risk assessment and security checklist. - No extra dependencies required.
元数据
Slug variant-pathogenicity-predictor
版本 0.1.0
许可证 MIT-0
累计安装 0
当前安装数 0
历史版本数 1
常见问题

Variant Pathogenicity Predictor 是什么?

Integrate REVEL, CADD, PolyPhen scores to predict variant pathogenicity. 它是一个面向 Claude Code / OpenClaw 的 AI Agent Skill 插件,目前累计下载 273 次。

如何安装 Variant Pathogenicity Predictor?

在 OpenClaw 或 Claude Code 对话框中运行命令「/install variant-pathogenicity-predictor」即可一键安装,无需额外配置。

Variant Pathogenicity Predictor 是免费的吗?

是的,Variant Pathogenicity Predictor 完全免费,采用 MIT-0 许可证,可自由下载、安装和使用。

Variant Pathogenicity Predictor 支持哪些平台?

Variant Pathogenicity Predictor 跨平台运行,可在任意部署了 OpenClaw / Claude Code 的环境中使用(cross-platform)。

谁开发了 Variant Pathogenicity Predictor?

由 EC-cyber258(@ec-cyber258)开发并维护,当前版本 v0.1.0。

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