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Celgene
by
hanxueyuan
· GitHub ↗
· v1.0.0
· MIT-0
49
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Install in OpenClaw
/install celgene
Description
Celgene transformed from near-bankruptcy chemical firm into a top biopharma, focusing on blood cancers with blockbuster drugs like Revlimid before BMS acquis...
README (SKILL.md)
Celgene — 医药行业最戏剧性的困境反转
概述
Celgene 的故事是生物医药行业最令人瞩目的转型案例之一：从 1980 年代濒临破产的精细化工公司，成长为年收入超过 150 亿美元的全球顶级生物制药企业，最终在 2019 年被百时美施贵宝（BMS）以约 740 亿美元收购。
历史时间线
- 1986年 — 从 Celanese Corporation 分拆成立
- 1990年代初 — 几乎破产，股价一度低于 $1
- 1995年 — 发现沙利度胺（Thalomid）在多发性骨髓瘤中的疗效，命运转折
- 2005年 — Revlimid（来那度胺）获批，后来成为全球最畅销的抗癌药物之一
- 2010年代 — 年收入从 $30 亿增长到超过 $150 亿
- 2019年 — BMS 以 $740 亿美元（每股 $108 + 换股）完成收购
- 2020年 — 品牌整合入 BMS，Celgene 作为独立公司消失
商业模式
- 血液瘤专注：Revlimid、Pomalyst、Abraxane 等核心产品聚焦多发性骨髓瘤
- 沙利度胺衍生物平台：基于 IMiD（免疫调节药物）的分子平台，持续开发新产品
- 自身免疫布局：拓展到银屑病、克罗恩病等自免领域
- 早期研发 + 并购补充：大量收购早期生物技术公司补充管线
护城河分析
- Revlimid 专利：在其专利期内（至 2022-2026 年，因和解延长），年销售超过 $100 亿
- 沙利度胺再发现：将一种臭名昭著的致畸药物转化为救命药物，这一科学突破难以复制
- 血液瘤专家网络：在全球血液肿瘤学界建立了深厚的 KOL 关系
关键数据
- 收购价格：约 $740 亿（BMS, 2019）
- 峰值年收入：超过 $150 亿
- 旗舰产品：Revlimid（年收入峰值超过 $120 亿）
- 员工数（被收购前）：约 9,000 人
- 总部：新泽西州 Summit
有趣事实
- Revlimid 是沙利度胺（Thalidomide）的衍生物 — 后者因 1950-60 年代的致丑闻被禁用，但 Celgene 的科学家发现其在癌症中的独特机制
- 在 Revlimid 专利到期后，BMS 面临仿制药冲击，这也是收购后的最大风险
Usage Guidance
This skill appears to be an informational/educational skill and is internally consistent with that purpose. It requests no credentials, performs no installs, and its instructions are limited to presenting company history and analysis. If you require provenance, note the skill's source/homepage are not provided (owner ID only); if that matters for trust, ask the publisher for a homepage or source repository before installing. Otherwise it is low-risk to enable for human-invoked use.
Capability Analysis
Type: OpenClaw Skill
Name: celgene
Version: 1.0.0
The skill bundle contains purely informational and educational content regarding the history, business model, and acquisition of the pharmaceutical company Celgene. There are no executable code snippets, network requests, or prompt injection attempts in SKILL.md or _meta.json.
Capability Assessment
Purpose & Capability
Name and description match the content of SKILL.md (a corporate/industry case study). There are no unexpected binaries, env vars, or config paths requested.
Instruction Scope
SKILL.md contains only background, timeline, analysis, and usage contexts (read_when). It does not instruct the agent to read unrelated files, call external endpoints, or collect secrets.
Install Mechanism
No install spec and no code files — nothing is written to disk or fetched during install. This is the lowest-risk pattern.
Credentials
The skill declares no required environment variables or credentials; nothing disproportionate is requested.
Persistence & Privilege
always is false and the skill is user-invocable. It does not request persistent/privileged presence or system configuration changes.
How to Use
- Make sure OpenClaw is installed (local or Docker)
- Run the install command in chat:
/install celgene - After installation, invoke the skill by name or use
/celgene - Provide required inputs per the skill's parameter spec and get structured output
Version History
v1.0.0
Celgene skill version 1.0.0 — 精要信息一览：
- 新增：全面介绍 Celgene 从化工公司到全球顶级生物医药企业的转型历程
- 覆盖关键时间线、商业模式、护城河及核心产品信息
- 详述 Revlimid 从沙利度胺再发现到 blockbuster 的全过程
- 汇集行业并购案要点及企业关键数据
- 添加适用场景及研究参考建议
Metadata
Frequently Asked Questions
What is Celgene?
Celgene transformed from near-bankruptcy chemical firm into a top biopharma, focusing on blood cancers with blockbuster drugs like Revlimid before BMS acquis... It is an AI Agent Skill for Claude Code / OpenClaw, with 49 downloads so far.
How do I install Celgene?
Run "/install celgene" in the OpenClaw or Claude Code chat to install it in one step — no extra setup required.
Is Celgene free?
Yes, Celgene is completely free, licensed under MIT-0. You can download, install and use it at no cost.
Which platforms does Celgene support?
Celgene is cross-platform and runs anywhere OpenClaw / Claude Code is available (cross-platform).
Who created Celgene?
It is built and maintained by hanxueyuan (@hanxueyuan); the current version is v1.0.0.
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