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Description
基于人民卫生出版社《生物化学与分子生物学》第10版的AI技能合集 — 154项核心技能，涵盖分子生物学、代谢调控、基因组学、临床诊断与精准医学。
README (SKILL.md)
《Biochemistry & Molecular Biology (PMPH 10th Edition)》Skill Collection
基于人民卫生出版社《生物化学与分子生物学》第10版的AI技能合集
本技能合集源自权威教材，涵盖 154 项核心技能，分为分子生物学基础、基因表达调控、代谢通路与调控、信号转导、基因组学与精准医学、临床生化与诊断等15大分类。
使用场景 / When to Use
本技能合集适用于以下场景：
教学与学习
- 医学生/研究生系统学习生物化学与分子生物学
- 教师备课、课堂互动与考试出题
- 解释代谢通路、信号转导等复杂机制
科研辅助
- 实验设计方案（PCR、克隆、表达、纯化）
- 代谢组学/基因组学分析策略
- 疾病相关基因功能分析
临床参考
- 代谢性疾病诊断与鉴别
- 精准医学与靶向治疗
- 临床生化检验结果解读
执行规则 / Execution Rules
技能调用
用户直接引用技能名称可触发对应专业知识。例如：
- "请解释 fructose-metabolism-pathways-and-pathological-risks 的关键酶"
- "基于 precision-medicine-four-layer-system 设计方案"
- "分析 fatty-acid-beta-oxidation-and-energy-yield-calculation 的ATP产量"
响应规则
- 结构化输出 — 每项技能输出包含：机制/原理、步骤/流程、临床/应用意义
- 教材引用 — 优先引用第10版教材内容，标注页码/章节
- 双语术语 — 核心术语首次出现时标注英文
- 风险评估 — 涉及临床诊断/用药的技能须标注风险提示
技能分类 / Skill Categories
| 分类 | 技能数 | 说明 |
|---|---|---|
| 🧬 分子生物学与基因表达调控 | 16 | DNA/RNA结构、转录、剪接、修饰 |
| 🔧 基因工程与重组DNA技术 | 8 | 克隆载体、限制酶、CRISPR、表达系统 |
| 🧪 基因组学与疾病基因分析 | 8 | GWAS、定位克隆、外显子测序、基因芯片 |
| 🏗️ 蛋白质结构与功能分析 | 7 | 一级结构、α-螺旋、构象病、磷酸化 |
| ⚗️ 代谢通路与调控 | 15 | 糖代谢、脂肪酸氧化、酮体、乙醇代谢 |
| 🧫 核酸与核苷酸代谢 | 7 | 嘌呤/嘧啶合成与分解、抗代谢药物 |
| 🫧 脂质与脂蛋白代谢 | 9 | LDL、HDL、胆汁酸、脂蛋白分类 |
| 📡 信号转导与细胞调控 | 10 | GPCR、离子通道、p53、PTEN、RB |
| 🧬 癌症生物学与精准医学 | 7 | 癌基因、多阶段致癌、精准医疗四层 |
| 🏥 临床生化与诊断 | 9 | OGTT、糖化血红蛋白、黄疸鉴别、脱水 |
| 🔬 酶学与分离技术 | 6 | 凝胶过滤、离子交换、P450、核酶 |
| 🦠 微生物与翻译机制 | 6 | 翻译起始、延伸、SRP、抗生素 |
| ⚡ 氧化还原与能量代谢 | 5 | 呼吸链、氧化磷酸化、P/O比、ATP |
| 🏋️ 内分泌与微量元素 | 4 | 碘双重功能、运动生理、肾上腺素 |
| 📚 医学教材与数字资源 | 6 | 教材修订原则、数字教材、元数据 |
| 🌟 其他特色技能 | 31 | 端粒酶、PCR、miRNA、组蛋白修饰等 |
完整技能注册表 / Full Skill Registry
以下是全部 154 项技能及其路径：
\x3Cdetails> \x3Csummary>\x3Cb>🧬 分子生物学与基因表达调控 (16)\x3C/b>\x3C/summary>
- dna-methylation-and-cpg-island-transcription-regulation
- eukaryotic-gene-expression-multi-level-regulation
- rna-polymerase-ii-preinitiation-complex-assembly
- nonsense-mediated-mrna-decay-mechanism
- alternative-splicing-mechanism-and-biological-significance
- rna-transcription-and-splicing
- eukaryotic-pre-trna-post-transcriptional-processing
- prokaryotic-transcription-initiation
- rna-intron-splicing-mechanisms
- spliceosome-mediated-pre-mrna-splicing
- eukaryotic-mrna-polyadenylation-and-transcription-termination
- abortive-transcription-initiation-analysis
- promoter-escape-vs-clearance-distinction
- rna-biosynthesis-template-dependent-modes
- rna-biosynthesis-terminology-bilingual-reference
- rna-biosynthesis-textbook-recommendation \x3C/details>
\x3Cdetails> \x3Csummary>\x3Cb>🔧 基因工程与重组DNA技术 (8)\x3C/b>\x3C/summary>
- recombinant-dna-construction
- e-coli-prokaryotic-expression-vector-design
- type-ii-restriction-enzyme-dna-cleavage
- fusion-tag-design-for-recombinant-protein-expression
- e-coli-expression-system-evaluation
- tong-wei-mei-yu-tong-qie-dian-mei-ying-yong
- crispr-cas9-targeted-gene-correction
- gst-pull-down-assay \x3C/details>
\x3Cdetails> \x3Csummary>\x3Cb>🧪 基因组学与疾病基因分析 (8)\x3C/b>\x3C/summary>
- classify-disease-related-genes
- gwas-analysis-for-complex-diseases
- positional-cloning-disease-gene-identification
- functional-vs-phenotypic-cloning-strategy-selection
- omim-entry-number-interpretation
- whole-exome-sequencing-analysis
- str-pcr-dna-fingerprinting
- apply-gene-chip-for-diagnosis \x3C/details>
\x3Cdetails> \x3Csummary>\x3Cb>🏗️ 蛋白质结构与功能分析 (7)\x3C/b>\x3C/summary>
- protein-primary-structure-similarity-inference
- alpha-helix-secondary-structure-analysis
- protein-conformational-disease-identification
- protein-reversible-phosphorylation-signaling
- enzyme-labeling-assay-enzyme-selection-and-application
- reversible-enzyme-inhibition-analysis
- calculate-dna-melting-temperature \x3C/details>
\x3Cdetails> \x3Csummary>\x3Cb>⚗️ 代谢通路与调控 (15)\x3C/b>\x3C/summary>
- fructose-metabolism-pathways-and-pathological-risks
- galactose-to-glucose-6-phosphate-metabolism
- pentose-phosphate-pathway-analysis
- pentose-phosphate-pathway-in-erythrocyte-antioxidant-defense
- fatty-acid-beta-oxidation-and-energy-yield-calculation
- glycogen-synthesis-and-breakdown-reciprocal-regulation
- substrate-cycle-hormonal-allosteric-regulation
- pasteur-vs-warburg-effect-regulation
- ethanol-metabolism-pathways-clinical-assessment
- starvation-energy-substrate-switch
- ying-ji-fen-jie-dai-xie-ji-zhi
- atp-neng-liang-dai-xie-he-xin-ji-zhi
- gan-zai-xue-tang-wen-tai-wei-chi-zhong-de-he-xin-ji-zhi
- myocardial-substrate-preference-regulation
- renal-gluconeogenesis-regulation \x3C/details>
\x3Cdetails> \x3Csummary>\x3Cb>🧫 核酸与核苷酸代谢 (7)\x3C/b>\x3C/summary>
- de-novo-purine-nucleotide-synthesis-regulation
- purine-nucleotide-catabolism-to-uric-acid
- pyrimidine-nucleotide-catabolism-analysis
- allopurinol-gout-treatment-dual-inhibition
- vitamin-pp-metabolism-and-toxicity-assessment
- cobalt-vitamin-b12-hematopoiesis-pathway
- vitamin-b2-deficiency-diagnosis-and-prevention \x3C/details>
\x3Cdetails> \x3Csummary>\x3Cb>🫧 脂质与脂蛋白代谢 (9)\x3C/b>\x3C/summary>
- tissue-specific-triglyceride-synthesis-pathways
- plasma-lipoprotein-structure-and-function-classification
- ldl-receptor-mediated-metabolism-pathway
- ldl-receptor-defect-familial-hypercholesterolemia-mechanism
- hdl-cholesterol-reverse-transport
- bile-acid-enterohepatic-circulation
- gut-bacterial-generation-of-secondary-bile-acids
- lipidomics-analysis-method-selection
- lipid-chromatography-separation \x3C/details>
\x3Cdetails> \x3Csummary>\x3Cb>📡 信号转导与细胞调控 (10)\x3C/b>\x3C/summary>
- second-messenger-generation-and-clearance
- growth-factor-signaling-modes
- gpcr-signal-transduction-basic-pathway
- ligand-gated-ion-channel-receptor-mechanism
- tp53-dna-damage-response-and-apoptosis-regulation
- rb-e2f-g1s-checkpoint-regulation
- pten-tumor-suppression-mechanism
- eif-phosphorylation-translation-regulation
- signal-transduction-cross-talk
- adenine-nucleotide-phosphate-cotransport \x3C/details>
\x3Cdetails> \x3Csummary>\x3Cb>🧬 癌症生物学与精准医学 (7)\x3C/b>\x3C/summary>
- oncogene-activation-mechanism-classification
- oncogene-functional-classification-in-growth-factor-pathways
- colon-cancer-multistage-carcinogenesis-model
- define-precision-medicine-goals
- precision-medicine-four-layer-system
- gene-therapy-ethics-and-regulatory-compliance
- duo-ji-yin-chang-jian-bing-de-ji-yin-zhi-liao-ce-lue \x3C/details>
\x3Cdetails> \x3Csummary>\x3Cb>🏥 临床生化与诊断 (9)\x3C/b>\x3C/summary>
- ogtt-diagnostic-criteria
- glycated-hemoglobin-diabetes-assessment
- jaundice-differential-diagnosis
- bilirubin-metabolism-and-jaundice-classification
- dehydration-severity-assessment
- amino-acid-isoelectric-point-calculation
- kai-shi-ding-nitrogen-protein-calculation
- lan-bai-shai-xuan-yuan-li
- gao-di-xue-tang-bian-bie-yu-chu-li \x3C/details>
\x3Cdetails> \x3Csummary>\x3Cb>🔬 酶学与分离技术 (6)\x3C/b>\x3C/summary>
- gel-filtration-chromatography-for-protein-separation
- ion-exchange-chromatography-for-protein-separation
- pfk1-allosteric-and-hormonal-regulation
- cytochrome-p450-monooxygenase-mechanism
- ribozyme-classification-and-catalytic-mechanism
- prokaryotic-rna-primer-removal-and-ligation \x3C/details>
\x3Cdetails> \x3Csummary>\x3Cb>🦠 微生物与翻译机制 (6)\x3C/b>\x3C/summary>
- prokaryotic-translation-initiation-complex-assembly
- peptide-chain-elongation-cycle
- srp-mediated-cotranslational-translocation
- eukaryotic-rna-polymerase-selection
- antibiotic-protein-synthesis-inhibition
- trna-structure-and-codon-recognition \x3C/details>
\x3Cdetails> \x3Csummary>\x3Cb>⚡ 氧化还原与能量代谢 (5)\x3C/b>\x3C/summary>
- complex-iv-oxygen-reduction-and-proton-pumping
- mitochondrial-electron-transport-and-proton-pumping
- oxidative-phosphorylation-coupling-sites-and-p-o-ratio
- mature-erythrocyte-energy-metabolism
- determine-atp-production-pathway-by-muscle-fiber-type \x3C/details>
\x3Cdetails> \x3Csummary>\x3Cb>🏋️ 内分泌与微量元素 (4)\x3C/b>\x3C/summary>
- iodine-dual-function-thyroid-hormone-antioxidant
- iodine-intake-imbalance-pathological-risk
- yundong-yilai-xing-il6-fenmi-he-duoxiao-zuoyong
- exercise-induced-epinephrine-secretion \x3C/details>
\x3Cdetails> \x3Csummary>\x3Cb>📚 医学教材与数字资源 (6)\x3C/b>\x3C/summary>
- design-digital-medical-textbook-strategy
- access-new-form-digital-medical-textbook-resources
- clinical-medical-textbook-revision-principles
- clinical-medical-textbook-revision-principles-2
- medical-textbook-structure-reorganization
- biochemistry-textbook-metadata-standard \x3C/details>
\x3Cdetails> \x3Csummary>\x3Cb>🌟 其他特色技能 (31)\x3C/b>\x3C/summary>
- dna-supercoiling-formation-and-function
- eukaryotic-dna-hierarchical-packaging
- glucuronidation-reaction-mechanism-and-clinical-application
- hepatic-biotransformation-pathway-analysis
- intestinal-ammonia-generation-and-ph-regulation
- eukaryotic-protein-degradation-pathways
- telomerase-inchworm-model-maintenance
- real-time-fluorescent-pcr-quantification
- pcr-amplification-and-applications
- mirna-sirna-rnai-mechanism-comparison
- shui-de-fan-chang-re-zhang-leng-suo-te-xing
- mrna-5-cap-structure-function
- glycosaminoglycan-structure-composition-rules
- lac-operon-dual-regulation
- trp-operon-repression-and-attenuation
- metabolomics-analysis-technology-selection
- metabolomics-analysis-level-selection
- obesity-metabolic-dysregulation-analysis
- glutamate-glutamine-cycle-mechanism
- astrocyte-glutamate-de-novo-synthesis
- shen-jing-zhuan-dao-yi-chang-ji-zhi-fen-xi
- 2-3-bpg-regulation-of-hemoglobin-oxygen-affinity
- hemoglobin-oxygen-binding-cooperativity
- glycogen-storage-disease-enzyme-phenotype-correlation
- galactosemia-enzyme-deficiency-classification
- renal-ketone-body-metabolism-regulation
- protein-targeting-signal-analysis
- dna-sequencing-technology-selection-and-medical-application
- histone-modification-gene-regulation
- eukaryotic-transcription-initiation-regulation
- eukaryotic-protein-degradation-pathways \x3C/details>
⚠️ 风险声明 / Risk Disclaimer
⚠️ 风险⚠️：本技能内容基于人民卫生出版社《生物化学与分子生物学》第10版整理，仅供教育学习参考。涉及临床诊断或治疗决策的内容须经合格临床医生审核。
⚠️ Risk ⚠️: This skill collection is based on the PMPH Biochemistry and Molecular Biology 10th Edition for educational reference only. Any clinical diagnostic or therapeutic decisions must be reviewed by qualified healthcare professionals.
安装 / Installation
# Coming soon — ClawHub CLI
# openclaw skills install biochemistry-molecular-biology-pmph-10edition
目录结构 / Directory Structure
Biochemistry-MolecularBiology-PMPH-10edition/
├── SKILL.md # 核心配置 — 154 项技能注册表（本文件）
├── README.md # 项目说明（中文）
├── README_EN.md # 说明（英文）
├── README_JP.md # 说明（日文）
├── README_FR.md # 说明（法文）
├── README_RU.md # 说明（俄文）
├── index.md # 完整技能索引表
├── \x3Cskill-name>/ # 各项技能的详细定义
│ └── SKILL.md # 技能详情（使用时机、执行步骤、参考文档）
├── assets/ # 静态资源
├── scripts/ # 可执行工具脚本
├── config/ # 配置文件
└── tests/ # 验证与测试
许可证 / License
本项目内容基于人民卫生出版社《生物化学与分子生物学》第10版整理，仅供学习参考。
© 2026 xllgreen — 基于人民卫生出版社教材 · Based on PMPH textbook
Usage Guidance
Install only if you want educational biochemistry and molecular-biology reference material and can keep medical, genetic, forensic, and wet-lab outputs under qualified human oversight. Do not use it as the sole basis for diagnosis, treatment, gene therapy design, forensic conclusions, or laboratory work involving hazardous chemicals or genetic manipulation.
Capability Assessment
Purpose & Capability
The overall purpose is coherent with education, research support, and clinical reference, but several individual skills move into treatment planning, diagnostic interpretation, gene therapy strategy, forensic DNA identification, and recombinant DNA/CRISPR workflow guidance.
Instruction Scope
The top-level files include an educational and clinician-review disclaimer, but multiple high-impact skills use imperative execution language and do not consistently require licensed clinical oversight, biosafety review, consent, privacy controls, or emergency escalation.
Install Mechanism
The artifact is composed of markdown skill files, declares no required binaries or config, has no executable files, and VirusTotal telemetry is clean.
Credentials
It does not request local file, credential, network, or execution access, but users may provide sensitive medical or genetic information when using the skills.
Persistence & Privilege
The metadata marks the collection as always active, which broadens when the medical guidance may influence responses, but there is no background process, privilege escalation, or system persistence.
How to Use
- Make sure OpenClaw is installed (local or Docker)
- Run the install command in chat:
/install biochemistry-and-molecular-biology-pmph-10edition - After installation, invoke the skill by name or use
/biochemistry-and-molecular-biology-pmph-10edition - Provide required inputs per the skill's parameter spec and get structured output
Version History
v1.0.0
- Initial release of the skill collection based on 《生物化学与分子生物学》第10版 by People's Medical Publishing House.
- Includes 154 core skills across 15 categories, covering molecular biology, metabolism, genomics, clinical diagnostics, and precision medicine.
- Each skill features structured responses: mechanisms, steps, clinical relevance, textbook references, and risk tips where applicable.
- Skill registry and bilingual terminology support for easier reference in education, research, and clinical practice.
- Designed for teaching, research assistance, and clinical applications.
Metadata
Frequently Asked Questions
What is Biochemistry and Molecular Biology-PMPH-10edition?
基于人民卫生出版社《生物化学与分子生物学》第10版的AI技能合集 — 154项核心技能，涵盖分子生物学、代谢调控、基因组学、临床诊断与精准医学。 It is an AI Agent Skill for Claude Code / OpenClaw, with 42 downloads so far.
How do I install Biochemistry and Molecular Biology-PMPH-10edition?
Run "/install biochemistry-and-molecular-biology-pmph-10edition" in the OpenClaw or Claude Code chat to install it in one step — no extra setup required.
Is Biochemistry and Molecular Biology-PMPH-10edition free?
Yes, Biochemistry and Molecular Biology-PMPH-10edition is completely free, licensed under MIT-0. You can download, install and use it at no cost.
Which platforms does Biochemistry and Molecular Biology-PMPH-10edition support?
Biochemistry and Molecular Biology-PMPH-10edition is cross-platform and runs anywhere OpenClaw / Claude Code is available (macos, linux, windows).
Who created Biochemistry and Molecular Biology-PMPH-10edition?
It is built and maintained by xllstudio (@xllgreen); the current version is v1.0.0.
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